Manchester United were sent crashing out of the Champions League last 16 in a 2-1 defeat against Sevilla at Old Trafford on Tuesday night.
Mourinho said: “I’ve sat in this chair twice in the Champions League after knocking out Manchester United in the last 16, with Real Madrid and with Porto. They were knocked out both times, it is nothing new for the club.
“I don’t have any regrets. I did my best, the players did their best. We tried, we lost and that is football.”
Sevilla substitute Wissam Ben Yedder scored twice for the Spanish side, seeing them in the draw for their first ever Champions League quarter-final.
Mourinho praised the substitutions made by the Spanish opposition: “Sometimes I am lucky with changes, other times other managers are. It was good, a happy move by Vincenzo to bring Ben Yedder on. When they scored the first goal the game is completely different.”
Manchester United legend Paul Scholes ripped into his former team saying: “It was very difficult watching that, it was difficult watching the first game. There’s no energy and no desire.”
Romelu Lukaku grabbed a late consolation goal for the home side in the 84th minute, but the travelling side defended admirably, limiting the Belgian’s chances.
United have been knocked out of the Champions League in the last 16 twice in their last three campaigns, failing to join the other qualified English teams, Manchester City and Liverpool.
With all United’s hopes of winning silverware now based on the FA Cup, with Manchester City all but over the Premier League line, The Red Devils will be focusing their targets on Saturday’s sixth round tie on Saturday against Brighton.